Novavax Covid vaccine extremely efficient in UK trial, drugmaker says
Maryland-based biotech firm Novavax reported Thursday that its investigational Covid-19 vaccine is over 96% efficient in stopping delicate and extreme sickness.
The outcomes come from the corporate’s Section 3 medical trial, which was performed within the UK. Trials of Novavax within the US and South Africa are persevering with, and the corporate can’t apply for a clearance of emergency use within the US till US testing is full.
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“We’re very inspired by the information,” mentioned Stanley Erck, president and CEO of Novavax, in a press release.
The UK trial included greater than 15,000 adults. Greater than 1 / 4 had been 65 or older, an age group typically thought of to be at greater danger for problems from Covid-19.
The 2-dose vaccine has been proven to be over 96% efficient in opposition to earlier strains of the virus circulating within the UK, placing it on par with vaccines already utilized by Moderna and Pfizer-BioNTech.
Efficacy was barely decrease – round 86% – in comparison with the extra contagious B.1.1.7 variant, which was first recognized within the UK The variant has already been detected in nearly half of the US states , and the Facilities for Illness Management and Prevention predicted that it will likely be the predominant variant by the tip of the month.
The Novavax vaccine was additionally 100% efficient in opposition to the extra extreme types of Covid-19, whatever the variant – identical to different vaccines utilized in the US.
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The Biden administration has promised sufficient vaccines for all eligible People by the tip of Could. The objective needs to be achieved with the vaccines already obtainable, from Moderna, Pfizer-BioNTech and Johnson & Johnson.
Different vaccines that in the end show to be efficient will probably be important for the well being and security of People in a post-Covid-19 atmosphere during which viruses can journey from nation to nation as quick as airplanes.
“The US will not be secure till the overwhelming majority of the remainder of the world is vaccinated,” mentioned John Grabenstein, former government director of medical affairs for vaccines at Merck and former Protection Division immunologist. .
Novavax additionally analyzed information from its Section 2b medical trial in South Africa, the place one other variant of SARS-CoV-2 was circulating. The variant, known as B.1.351, is of concern to scientists as a result of it seems to lower the effectiveness of the vaccine. Novavax has discovered that their vaccine is about 50% efficient in opposition to the variant.
The Novavax vaccine differs barely from different vaccines used. The Pfizer, Moderna, and Johnson & Johnson vaccines all present the physique with directions to construct the coronavirus spike protein, which the immune system learns to acknowledge and combat off. The Novavax vaccine ignores directions and delivers the spike protein on to the physique.
If in the end accredited to be used, the Novavax vaccine might function “one other defend we are able to use to guard ourselves in opposition to a nasty virus,” Grabenstein mentioned.
Greater than 98 million doses of vaccines have been administered, based on the CDC, with almost 34 million individuals having been totally immunized.
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